Synthesis of heterocyclic compounds. A cyclisation involving a lactam nitrogen in a derivative of isoquinolin-3-one

Abstract

1-Ethoxycarbonylalkyl derivatives of indan-2-one were prepared and converted, by the Schmidt reaction, into the corresponding 1-substituted 1,2-dihydroisoquinolin-3(4H)-ones. 1-Ethoxycarbonylethyl-1,2-dihydroisoquinolin-3(4H)-one gave 1,10b-dihydropyrrolo[2,1-a]isoquinoline-3(2H),5(6H)-dione by a cyclisation at the lactam nitrogen.