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Issue 9, 1970
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Potentially chemotherapeutic purine analogues. Part V. Some hydrazone derivatives of pyrazole-4,5-diones and their cyclisation to pyrazolo-[3,4-e][1,2,4]triazines

Abstract

4-Thiosemicarbazones of pyrazole-4,5-diones are prepared by the reaction of thiosemicarbazide with the diones themselves or with 4-p-diethylaminophenylimino-, 4-hydroxyimino-, or 4,4-dibromo-pyrazol-5-one. Cyclisation of 4-thiosemicarbazonopyrazol-5-ones under alkaline conditions leads to pyrazolo [3,4-e][1,2,4]triazine-3-thiols. The latter and their derivatives are of interest as potentially chemotherapeutic purine analogues.

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Article type: Paper
DOI: 10.1039/J39700001313
Citation: J. Chem. Soc. C, 1970,0, 1313-1315

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    Potentially chemotherapeutic purine analogues. Part V. Some hydrazone derivatives of pyrazole-4,5-diones and their cyclisation to pyrazolo-[3,4-e][1,2,4]triazines

    J. H. Lister, D. S. Manners and G. M. Timmis, J. Chem. Soc. C, 1970, 0, 1313
    DOI: 10.1039/J39700001313

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