Phenylalanine, but not o- or m-tyrosine or 2,3-dopa, is incorporated into gliotoxin with very high efficiency, allowing the use of heavy-isotope labelling methods: all five aromatic hydrogens are retained in the incorporation of phenylalanine, and biosynthesis by way of a 2,3-epoxide now appears plausible.
J. D. Bu'Lock and A. P. Ryles, J. Chem. Soc. D, 1970, 1404 DOI: 10.1039/C29700001404
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