The biosynthesis of mycophenolic acid
Abstract
Incorporation experiments with [7-14C]-5,7-dihydroxyphthalide (II), [7-14C]-6-gerany-5,7-dihydroxyphthalide (IV), [7-14C]-5,7-dihydroxy-4-methylphthalide (V), and [7-14C]-7-hydroxy-5-methoxy-4-methylphthalide (VI) suggest that only [7-14C]-5,7-dihydroxy-4-methylphthalide (V) acts as the principal precursor of mycophenolic acid.