Twofold metallation of 2-hydroxy-4-methylpyrimidines to form a new class of synthetically useful dianions
Abstract
Twofold metallation of 2-hydroxy-4-methylpyrimidines (Ia,b) with n-butyl-lithium or sodium amide produces dianions (IIa,b), which can serve as potentially versatile synthetic intermediates by virtue of their selective carbon–carbon condensations with electrophiles.