The Witting reaction between resonance-stabilised phosphoranes and steroid ketones under acid catalysis has been studied. Only ethoxycarbonylmethylene- and cyanomethylene-triphenylphosphorane and 3-oxo-steroids having no α-substituents can be successfully employed in this reaction. The stereochemistry of the olefin produced is the same as in the corresponding Wittig reaction conducted under basic conditions.
A. K. Bose, M. S. Manhas and R. M. Ramer, J. Chem. Soc. C, 1969, 2728 DOI: 10.1039/J39690002728
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