Substituted thiophens carrying adjacent amino- and cyano-groups have been converted into the corresponding pyrimidinethione derivatives in 30–70% yield by condensation with thioamides. Acylation of the thiophen followed by cyclisation in acidic solution gave the corresponding pyrimidones. The same reactions were used successfully with analogous furan compounds.
M. S. Manhas, V. V. Rao, P. A. Seetharaman, D. Succardi and J. Pazdera, J. Chem. Soc. C, 1969, 1937 DOI: 10.1039/J39690001937
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