Total synthesis of O-methylflavinantine
Abstract
The diazotisation of 6,7-dimethoxy- and 7-ethoxy-6-methoxy-1-(2-amino-4,5-dimethoxybenzyl)-1,2,3,4-tetrahydro-2-methylisoquinoline (XIII) and (XVIII), followed by thermal decomposition of the resulting diazonium salt, gave O-methylflavinantine (VI), whose synthesis has proved structure (IV) for flavinantine to be correct.