Heterocyclic syntheses by high temperature dehydrocyclisation of amines and imines with iodine. Part I. Pyridine
Abstract
The stoicheiometric reaction of suitable aliphatic amines or imines with iodine at 400–600° produces pyridine. In the presence of calcium oxide, which removes the hydrogen iodide also formed, a yield of pyridine of 65% may be obtained. Addition of oxygen permits the use of less than the stoicheiometric quantity of iodine. A mechanism is proposed.