Potential coenzyme inhibitors. Part II. Reduction of 4-methylnicotinamide derivatives by sodium dithionite and sodium borohydride
Abstract
The preparation of some 4-methylnicotinamide derivatives is described, and the dithionite and borohydride reduction products are compared with those from the corresponding nicotinamide derivatives. The u.v. absorption and 1H n.m.r. spectra show that in each case 1,4-dihydronicotinamides are formed from the dithionite reactions, whilst borohydride reductions yield 1,6-dihydro-derivatives.