Assignment of configurations to the 1,3,4,7-tetramethylisoindolines by use of nuclear magnetic resonance spectroscopy
Abstract
The configurations of the 1,3,4,7-tetramethylisoindolines have been assigned on the basis of the equivalence or otherwise of the methylene protons in the N-benzyl and N-neopentyl derivatives. The isomer of lower m.p. has the cis-configuration. The acid-catalysed thermal equilibration of the isomers has been demonstrated.