The conformational analysis of saturated heterocycles. Part XVI. A simple quantitative approach to intramolecular interactions

Abstract

The relative importance of the following ‘standard interactions’ is elucidated: gauche butane (known), propane, gauche propylamine, and ethylamine. Axial–equatorial equilibria are thence predicted for aminocyclohexane, its N-methyl derivatives, and other compounds. Results are compared with experimental data (some new) and the conclusion that N-substitution in aminocyclohexane increases the proportion of axial conformer is discussed.