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Issue 0, 1966
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Constituents of Withania somnifera Dun. Part VI. The stereochemistry of withaferin A

Abstract

Withaferin A, the steroidal lactone isolated from the leaves of Withania somnifera Dun. (Solanaceae), has been degraded to bisnor-(5α)-cholanic acid. The β-orientation of the 5,6-epoxide has been demonstrated by optical rotatory dispersion and n.m.r. data. Consequently, withaferin A is a 5β-steroid with the usual stereochemistry at all asymmetric centres, possessing a six-membered-ring lactone in the side-chain.

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J. Chem. Soc. C, 1966, 1753-1756
Article type
Paper

Constituents of Withania somnifera Dun. Part VI. The stereochemistry of withaferin A

D. Lavie, S. Greenfield and E. Glotter, J. Chem. Soc. C, 1966, 1753
DOI: 10.1039/J39660001753

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