Esters of 2-alkyl-Δ2-thiazoline-4-carboxylic acids are smoothly dehydrogenated by phenanthraquinone to the corresponding thiazole derivatives. Methyl 2-benzamidomethyl-Δ2-thiazoline-4-carboxylate is dehydrogenated only slowly by phenenthraquinone but rapidly by manganese dioxide. The possible application of these reactions to the detection of thiazoline rings in peptides is discussed.
M. A. Barton, G. W. Kenner and R. C. Sheppard, J. Chem. Soc. C, 1966, 1061 DOI: 10.1039/J39660001061
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