A combination of proton-resonance-spectroscopic and dipole-moment measurements confirms that tropanes exist with the piperidine ring in a chair conformation and with the N-methyl substituent predominantly equatorial. A 3α-substituent causes considerable ring deformation.
R. J. Bishop, G. Fodor, A. R. Katritzky, F. Soti, L. E. Sutton and F. J. Swinbourne, J. Chem. Soc. C, 1966, 74 DOI: 10.1039/J39660000074
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