Correction: Discovery of fully synthetic FKBP12-mTOR molecular glues

Robin C. E. Deutscher; Christian Meyners; Maximilian L. Repity; Wisely Oki Sugiarto; Jürgen M. Kolos; Edvaldo V. S. Maciel; Tim Heymann; Thomas M. Geiger; Stefan Knapp; Frederik Lermyte; Felix Hausch

doi:10.1039/D6SC90062C

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DOI: 10.1039/D6SC90062C (Correction) Chem. Sci., 2026, Advance Article

Correction: Discovery of fully synthetic FKBP12-mTOR molecular glues

Robin C. E. Deutscher^a, Christian Meyners^a, Maximilian L. Repity^a, Wisely Oki Sugiarto^a, Jürgen M. Kolos^a, Edvaldo V. S. Maciel^a, Tim Heymann^a, Thomas M. Geiger^a, Stefan Knapp^bcd, Frederik Lermyte^a and Felix Hausch*^ae
^aInstitute for Organic Chemistry and Biochemistry, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287 Darmstadt, Germany. E-mail: felix.hausch@tu-darmstadt.de
^bInstitut für Pharmazeutische Chemie, Goethe-University Frankfurt, Biozentrum, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
^cStructural Genomics Consortium, Goethe-University Frankfurt, Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany
^dGerman Cancer Consortium (DKTK)/German Cancer Research Center (DKFZ), DKTK Site Frankfurt-Mainz, 69120 Heidelberg, Germany
^eCentre for Synthetic Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany

Received 2nd March 2026 , Accepted 2nd March 2026

First published on 23rd March 2026

Abstract

Correction for ‘Discovery of fully synthetic FKBP12-mTOR molecular glues’ by Robin C. E. Deutscher et al., Chem. Sci., 2025, 16, 4256–4263, https://doi.org/10.1039/D4SC06917J.

The authors regret that there is an error in Table 1 of the article, within the heading of the fifth column. The units for EC^{ternary nanoBRET}₅₀ should be nM. Furthermore, a citation to ref. 58 should be present. The correct version of Table 1 is displayed below.

Table 1 Biochemical and cellular characterization of FKBP12-FRB molecular glues. Affinities for compounds binding to purified human FKBP12 were determined by a competitive FP assay (K^FP_i).⁵⁶ Biochemical potencies for ternary complex induction were determined using a FP assay by titrating purified FRB with compound-bound fluorescently labelled FKBP12 (EC^{ternary FP}₅₀). Intracellular potencies for FKBP12 occupancy were determined by a competitive NanoBRET assay (IC^nanoBRET₅₀)⁵⁷ and potencies for intracellular formation of FKBP12-compound-FRB ternary complexes were determined by HEK293T cells transiently expressing a FKBP12-nLuc and FRB-HaloTag BRET pair (EC^{ternary nanoBRET}₅₀). n.b. = non-binding, n.m. = not measured

No.	Human FKBP12, K^FP_i/nM⁵⁶	EC^{ternary FP}₅₀/µM	FKBP12 IC^NanoBRET₅₀/nM⁵⁷	EC^{ternary NanoBRET}₅₀/nM⁵⁸
Rapamycin 1	0.6	0.039 ± 0.006	30.3 ± 1.5	1.8 ± 0.16	—
7	6.3	93 ± 21	81.2 ± 16.3	n.b.
9a	5.8	56 ± 10	40.6 ± 5.3	n.m.
9b	3.6	54 ± 6	47.8 ± 10.7	n.m.
10a	11	50 ± 5	405 ± 219	n.b.
10b	13	63 ± 6	101 ± 19	n.m.
10c	5.1	7.8 ± 2.6	146 ± 28.5	n.b.
10d	4.5	4.1 ± 0.4	25.5 ± 3.0	50.5 ± 9.8
10e	6.9	2.0 ± 0.2	57.3 ± 16.8	38.8 ± 1.7
10f	1.8	1.9 ± 0.2	259 ± 37	28.2 ± 1.3
10g	4.7 ± 1.8	1.8 ± 0.1	49.2 ± 4.0	26.0 ± 1.6
10h	0.8	1.5 ± 0.2	66.9 ± 22.5	31.7 ± 2.5
10i	0.4	1.3 ± 0.2	264 ± 36.8	172 ± 36
10j	7.2 ± 1.7	0.63 ± 0.06	799 ± 183	57.5 ± 3.6
10k	4.1 ± 0.6	0.56 ± 0.03	314 ± 21	26.3 ± 1.3
10l	4.5	0.53 ± 0.07	527 ± 77	32.9 ± 2.5
10m	6.0	0.23 ± 0.03	952 ± 147	31.7 ± 2.1
10n	4.8 ± 0.8	0.18 ± 0.02	1330 ± 195	42.1 ± 2.8
10o	2.6	0.17 ± 0.02	7460 ± 2100	109 ± 6.3

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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