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DOI: 10.1039/D6SC90031C
(Correction)
Chem. Sci., 2026, Advance Article
Correction: A mitochondria targeted nitroreductase-sensitive self-immolative spacer as an efficient shuttle for uncharged amine-based molecules
Laurane Michel,
Vincent Steinmetz,
Sophia Godel-Pastre,
Philippe Durand and
Arnaud Chevalier*
Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, Gif-sur-Yvette, 91198, France. E-mail: arnaud.chevalier@cnrs.fr
Received
2nd February 2026
, Accepted 2nd February 2026
First published on 12th February 2026
Abstract
Correction for ‘A mitochondria targeted nitroreductase-sensitive self-immolative spacer as an efficient shuttle for uncharged amine-based molecules’ by Laurane Michel et al., Chem. Sci., 2025, 16, 18383–18389, https://doi.org/10.1039/D5SC03665H.
The authors regret that an error occurred in the transcription of the values reported in Table 2c. The reported fluorescence QY values for compound 4-ANI were underestimated. The corrected values are provided in Table 2c of Fig. 2.
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| Fig. 2 Synthesis, photophysical characterization and in vitro enzymatic conversion of ratiometric fluorogenic probes 5a–c. (a) Synthesis of a 4-ANI-based fluorogenic probe (5a–c) and principle of ratiometric response to NTR. (b) Schematic representation of a 96-well plate illustrating the fluorescence emission color change associated with the release of 4-ANI following the enzymatic activation of probes 5a–c. (c) Photophysical properties of probes 5a–c and 4-ANI measured in PBS buffer and DMSO at 25 °C. Relative QYFl were calculated using quinine sulfate (QYFl = 0.59 in HClO4 0.1 M)28 for probes 5a–c or coumarin 153 (QYFl = 0.53 in EtOH)28 for 4-ANI. (d) Kinetic monitoring of NTR activation (1 µg) of probes 5a–c (10 µM in PB buffer pH = 7.4 + NADH 500 µM). The fluorescence was recorded over time at 540 nm with excitation fixed at 435 nm. (e) Emission spectra of probes 5a–c upon excitation at 405 nm recorded before and after incubation for 4 h with NTR in the presence of NADH (500 µM). (f) Inhibition effect of dicoumarol on 5b activation by NTR (fluorescence was recorded over time at 540 nm with excitation fixed at 430 nm). (g) Comparison of fluorescence intensity recorded after 30 min of incubation with multiple reducing agents at 37 °C. (h) UHPLC/MS analysis of the NTR-mediated transformation of probe 5c, giving the corresponding fluorophore 4-ANI through the hydroxylamine intermediate 5b′ and corresponding MS spectra. | ||
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