One stone, two birds: diverse glycopeptide synthesis via radical Ullmann coupling from serine

Abstract

The synergistic integration of synthetic efficiency with structural diversity constitutes a paramount objective in modern glycopeptide chemistry. Herein, we reports a two-in-one strategy to streamline glycopeptide synthesis by sequentially modifying identical peptide precursors. The method achieves one-step dual functionalization, fast construction of glycopeptide libraries, and delivers low-toxicity products, verifying its promising practical application prospects.