Pd-catalyzed site-selective dehydrogenative alkenyl etherification of tyrosine residues in peptides and proteins

Abstract

We report a palladium-catalyzed selective cross-coupling alkenyl etherification of the C(sp²)–O bond in tyrosine side chains, enabling the synthesis of diverse tyrosine-derived alkenyl ethers in moderate to good yields. This transformation provides a convenient strategy for introducing functional groups into peptides and proteins.