Cu(ii)-catalyzed [3 + 2] cycloaddition of enaminones and N-tosylaziridines leading to2,3-dihydropyrroles

Abstract

A copper-catalyzed [3 + 2] cycloaddition reaction between N-tosylaziridines and enaminones has been developed for the synthesis of functionalized 2,3-dihydropyrroles under ambient conditions. This approach proceeds via a facile nucleophilic ring-opening step and tolerates a range of enaminones bearing diverse functional groups and substitution patterns.