Palladium-catalyzed four-component cascade cyclization and carbonylation of bicyclobutyl (BCB) amides

Abstract

A novel palladium-catalyzed four-component cascade cyclization and carbonylation of bicyclobutyl (BCB) amides has been developed for the rapid construction of functionalized spiroquinolinone scaffolds. The reaction of bicyclobutyl (BCB) amides with perfluorobutyl iodide and phenols using formic acid as the CO source proceeded smoothly to afford a wide range of ester- and perfluoroalkyl-containing spiroquinolinone derivatives in high yields.