Benzophenone-catalyzed alkenylative pyridylation of vinylarenes with alkenylboronic esters

Abstract

We report a mild three-component reaction system combining styrenes, alkenylboronic esters, and 4-cyanopyridine for the efficient synthesis of alkenes. Furthermore, we demonstrate the practical utility of this methodology through its application in the synthesis of 1,1-diarylalkanes using alkylboronic esters and its scalability and compatibility with late-stage functionalization of pharmaceutical molecules.