Ligand-controlled copper-catalyzed carboamination reactions of styrenes and 1,3-enynes to access diverse imides

Abstract

The multi-component reaction among alkenes, nitriles and carboxylic acids via the radical Ritter-type process is one of the most convenient and efficient methods for obtaining imides. However, these multi-component reactions still have some drawbacks, such as a limited substrate scope. More importantly, new strategies and methods should be developed to achieve selective multi-component reactions. Herein, we described a ligand-controlled copper-catalyzed multi-component reactions to access diverse imides via HAT strategy from the readily available starting material. The present method exhibits a broad substrate scope for alkenes and 1,3-enynes with good functional group compatibility, high atomic economy and excellent late-stage molecular modifications, demonstrating the significant advantages in practical utility.