Copper-catalyzed selective 1,2-disulfidation of 1,3-dienes

Abstract

A copper-catalyzed protocol for the regioselective 1,2-bis-sulfuration of 1,3-dienes has been developed. This transformation utilizes sulfonyl chlorides and thiols as bifunctional sulfur sources, proceeding under mild conditions to afford valuable bis-sulfurated frameworks. Mechanistic investigations suggest a radical-mediated process, highlighting that the conjugated diene moiety is essential for the efficacy of this protocol. This method provides a versatile and efficient approach for the installation of diverse sulfur functionalities onto conjugated diene skeletons in a single synthetic operation.