Pd(ii)-catalyzed oxidative cyclization of amino alcohols with 1,3-cyclohexadiene: a route to fused morpholine derivatives

Abstract

We have developed an efficient and concise synthetic strategy for the rapid construction of morpholine-fused bicyclic scaffolds under mild aerobic conditions via Pd(II)-catalyzed oxidative cyclization of 1,3-cyclohexadiene with amino alcohol substrates. This protocol enables direct 1,2-aminooxygenation of cyclic dienes, providing access to a range of fused morpholine derivatives with good regioselectivity and yields.