Substituent effects direct anion transport in aryl-triazole derivatives

Abstract

A series of aryl triazole derivatives with varying electronic substituents but comparable hydrophobicity were synthesized for chloride transmembrane transport. Their activity decreased as the electron-withdrawing strength weakened (EC₅₀ ranging from 3.2 to 15.2 μM), establishing a clear structure–activity relationship and providing a key basis for designing efficient artificial anion transporters.