Dual strategy approach for an aliphatic nitrile directing group-assisted palladium-catalyzed meta-C–H arylation/acetoxylation of arenes

Abstract

The meta-selective arylation of simple aliphatic nitrile-bearing arylmethanesulfonic acid derivatives under microwave-accelerated conditions has been developed. Additionally, the meta-arylation of 3-phenylpropanoic acid esters tethered to a nitrile template was achieved under conventional heating conditions. Furthermore, the feasibility of meta-acetoxylation was tested. Moreover, the strategy was found to be suitable for achieving drug diversification.