One-pot multicomponent synthesis of indole-linked fully substituted fused pyrroles

Abstract

Indoles and pyrroles are valued owing to their natural and pharmaceutical abundance and impressive biological profile. Herein, we report the green and sustainable non-templated synthesis of indole-linked fully substituted fused pyrroles by the multicomponent reactions of arylglyoxals, dimedone, indoles, and anilines. The notable features of the present method include the formation of four new bonds (2 C–C, 2 C–N) under one-pot, catalyst-, and metal-free reaction conditions, and easy isolation of the products by filtration, gram-scale synthesis, and synthesis of pharmaceutically relevant scaffolds.