Synthesis of 2-aminobenzothiazole substituted indoles via DBU catalyzed addition of indoles and benzothiazolimines

Abstract

A DBU-catalyzed Mannich reaction between indoles and benzothiazolimines has been developed, providing an efficient and practical approach to access a series of 2-aminobenzothiazole substituted indoles with potential pharmaceutical relevance. Under mild reaction conditions, the protocol affords the desired products in moderate to excellent yields (up to 90%) and is readily scalable to the gram scale without significant loss of efficiency.