Chiral amine-urea mediated asymmetric inverse-electron-demand cycloadditions of cyclic nitrones with o-hydroxystyrenes

Abstract

Asymmetric inverse-electron-demand cycloaddition reactions of cyclic nitrones with o-hydroxystyrenes have been developed using a quinine-derived chiral amine-urea. The high levels of asymmetric induction are found to be afforded by an Anti-Open-S mechanism involving a dual activation system.