Hyaluronic acid-based nanofibrous scaffolds incorporating Nigella sativa methanolic extract with multifunctional antimicrobial, antioxidant, anti-inflammatory, and anticancer properties for advanced wound healing

Hadil Faris Alotaibi; Fadhil Faez Sead; Farag M. A. Altalbawy; Nawfal Yousif Jamil; Ahmed Salih Sahib; Umida Tashkenbaeva; Zahraa Saad Abdulali; Mariem Alwan; Mahmood Jawad; Hiba Mushtaq; Aseel Smerat; Samar El-Tayeb Izzat

doi:10.1039/D6NJ00537C

Hyaluronic acid-based nanofibrous scaffolds incorporating Nigella sativa methanolic extract with multifunctional antimicrobial, antioxidant, anti-inflammatory, and anticancer properties for advanced wound healing

Hadil Faris Alotaibi,^a Fadhil Faez Sead,^b Farag M. A. Altalbawy,^c Nawfal Yousif Jamil,^d Ahmed Salih Sahib,^ef Umida Tashkenbaeva,^g Zahraa Saad Abdulali,^h Mariem Alwan,ⁱ Mahmood Jawad,^j Hiba Mushtaq,^k Aseel Smerat^ln and Samar El-Tayeb Izzat

*^m

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint AbdulRahman University, Riyadh 11671, Saudi Arabia

^b Department of Dentistry, College of Dentistry, The Islamic University, Najaf, Iraq

^c Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia

^d Health and Medical Techniques College, Alnoor University, Nineveh, Iraq

^e College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq

^f Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq

^g Department of Dermatovenerology and Cosmetology N1, Tashkent State Medical University, Tashkent, Uzbekistan

^h College of Health and Medical Technology, National University of Science and Technology, Dhi Qar, Iraq

ⁱ Pharmacy College, Al-Farahidi University, Baghdad, Iraq

^j Department of Pharmacy, Al-Zahrawi University, Karbala, Iraq

^k Gilgamesh Ahliya University, Baghdad, Iraq

^l Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, India

^m Department of Pharmaceutical Chemistry, University of Khartoum, Khartoum, Sudan
E-mail: samar.e.izzat@gmail.com

ⁿ Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman 19328, Jordan

Abstract

The present study reports the fabrication and characterization of hyaluronic acid nanofibers incorporated with Nigella sativa methanolic extract (HA/NSME-nanofibers) for potential skin therapeutic applications. The HA/NSME-nanofibers were successfully electrospun and systematically characterized in terms of morphology, mechanical properties, surface wettability, and chemical interactions. The bioactive properties of the fibers, including antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer activities, were assessed, demonstrating promising multi-functional behavior suitable for wound healing and skin tissue engineering. Incorporation of plant-derived bioactive compounds into biopolymeric fibers provides a synergistic platform for developing advanced wound dressings.

New Journal of Chemistry

Hyaluronic acid-based nanofibrous scaffolds incorporating Nigella sativa methanolic extract with multifunctional antimicrobial, antioxidant, anti-inflammatory, and anticancer properties for advanced wound healing

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Hyaluronic acid-based nanofibrous scaffolds incorporating Nigella sativa methanolic extract with multifunctional antimicrobial, antioxidant, anti-inflammatory, and anticancer properties for advanced wound healing

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