Triphenylphosphine-mediated Ir/Ni dual photoredox–catalyzed C(sp2)–C(sp3) coupling of alkyl alcohol and aryl bromide

Abstract

Herein, we present a mild C(sp²)–C(sp³) coupling methodology from alkyl alcohol and aryl bromide under blue-light irradiation. The triphenylphosphine-mediated alkyl radical generated under photochemical conditions was coupled with aryl bromide in the presence of Ni/dtbpy as a catalyst system to provide the C–C coupled product in moderate to good yields. Optimization of substrate scope under these conditions showed that a range of aryl and hetero aryl bromides could be coupled successfully with functionalized benzyl alcohols and other aliphatic alcohols.