HCO2H-promoted hydrolysis of 2-chloroquinolines to quinolones

Abstract

Heterocyclic quinolones are ubiquitous in nature and are vital structural motifs with widespread applications in organic synthesis and pharmaceuticals. Herein, a practical and efficient method for the synthesis of quinolones via HCO₂H-promoted hydrolysis of 2-chloroquinolines is established. This transformation provides direct access to quinolones from 2-chloroquinolines under simple conditions. This method enables a concise and scale-up synthesis of an antileishmanial molecule.