Facile access to 3,5-disubstituted 1,2,4-thiadiazoles via T3P®-mediated oxidative dimerization of thioamides

Abstract

A series of propyl phosphonic anhydride (T3P®)-mediated oxidative dimerization reactions, of aromatic and aliphatic thioamides, for the efficient synthesis of 3,5-disubstituted 1,2,4-thiadiazoles has been developed. T3P® has been demonstrated to be an efficient, greener, safer and practical reagent for this transformation, affording good yields under mild conditions. Overall, this approach provides an environmentally benign route to 3,5-disubstituted 1,2,4-thiadiazoles.