Bioactive thiolated mesoporous silica@l-arginine modified sodium alginate/guar gum thin films for blood compatible wound healing

Abstract

Wound healing is a significant worldwide health issue that may complicate the regular activities of human life. Notwithstanding the widespread availability of several wound healing materials, the quest for an optimum blood compatible wound healing substance persists. This study aims to develop an optimal wound healing material that is blood compatible, exhibiting enhanced biocompatibility and wound healing efficacy. Sodium alginate (SA) is utilized for its efficacious healing properties and its capacity to sustain a moist microenvironment. It is additionally functionalized with L-arginine to augment the production of collagen, epithelialization and wound healing. L-Arginine-modified SA is subsequently mixed with guar gum (GG) to improve its characteristics. Thiol-functionalized mesoporous silica nanoparticles were utilized for their enhanced antioxidant capacity and hemocompatibility. The solvent casting method is adopted for the preparation of films. The prepared films and the nanocomposites underwent physicochemical and biomedical characterization to confirm their suitability for wound healing applications. The hemocompatibility studies show 92% compatibility with blood and the resultant material exhibits 86% wound closure over 24 hours. The evaluations explain that the prepared thiolated mesoporous silica@L-arginine modified SA/GG thin films are ideal for wound healing applications. In the future, advancing in vivo investigations will be crucial for clinical applications.