Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

Abdul Salam; Goraksha T. Sapkal; Bodhidipra Mukherjee; Sakshi Chouhan; Richa Garg; Shilpa Chandra; Chayan Kanti Nandi

doi:10.1039/D6DT00345A

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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

Abdul Salam,

^a Goraksha T. Sapkal,

^a Bodhidipra Mukherjee,

^a Sakshi Chouhan,

^a Richa Garg,

^a Shilpa Chandra

^a and Chayan Kanti Nandi

*^a

Author affiliations

* Corresponding authors

^a School of Chemical Sciences, Indian Institute of Technology (IIT), Mandi, H.P.-175005, India
E-mail: Chayan@iitmandi.ac.in

Abstract

The endoplasmic reticulum (ER) undergoes dynamic morphological changes during cellular stress and disease, yet specific staining and nanoscale observation are challenging. Here, we report a highly bright, biocompatible, and nontoxic fluorescent Zn-complex for super-resolution imaging of the ER. Super-resolution radial fluctuation microscopy (SRRF) resolved the smallest tubular diameter of the ER (110 nm) and quantified stress-induced morphological remodeling.

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DOI: https://doi.org/10.1039/D6DT00345A
Article type: Paper
Submitted: 09 Feb 2026
Accepted: 23 Mar 2026
First published: 24 Mar 2026

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Dalton Trans., 2026, Advance Article

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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

A. Salam, G. T. Sapkal, B. Mukherjee, S. Chouhan, R. Garg, S. Chandra and C. K. Nandi, Dalton Trans., 2026, Advance Article , DOI: 10.1039/D6DT00345A

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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

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