Cooling cocrystallization of acetazolamide & p-aminobenzoic acid in continuous slug flow crystallizer
Abstract
Continuous production of the 1 : 1 acetazolamide (ACZ) : p-aminobenzoic acid (PABA) cocrystal was achieved via cooling cocrystallization in a tubular slug flow crystallizer, under conditions mimicking batch cooling crystallization. Regulating the ACZ : PABA feed ratio was the critical parameter that yielded pure cocrystals within 15 minutes of residence time.

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