A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

Yuqing Hu; Qiu-Lian Hao; Xiaohang Wang; Xin-Rong Li; Zixuan Xu; Lu-Lu Sun; Tianlin Ni; Xianzhi Chai; Hai-Hao Han; Junji Zhang

doi:10.1039/D6CC02864K

A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

Yuqing Hu,†^a Qiu-Lian Hao,†^b Xiaohang Wang,^a Xin-Rong Li,^b Zixuan Xu,^a Lu-Lu Sun,^b Tianlin Ni,^a Xianzhi Chai,

*^a Hai-Hao Han

*^bc and Junji Zhang

*^d

Author affiliations

* Corresponding authors

^a School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, China
E-mail: 2621993143@qq.com, 3261542866@qq.com, 2942977946@qq.com, 1911767109@qq.com, chaixianzhi@163.com

^b Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China
E-mail: qlhao@baridd.ac.cn, 13577436189@163.com, llsun@baridd.ac.cn, hanhaihao@simm.ac.cn

^c Molecular Imaging Center, State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

^d Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China
E-mail: zhangjunji@ecust.edu.cn

Abstract

A ratiometric near-infrared probe, CCy7-DP, was developed for peroxynitrite detection, utilizing a highly selective addition–elimination reaction between ONOO⁻ and diphenyl phosphinate. This reaction triggered an electron rearrangement of the cyanine skeleton and a blue shift in fluorescence, enabling high-contrast imaging of peroxynitrite in the brains of epileptic mice.

Chemical Communications

A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

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A highly selective near-infrared fluorescent probe for imaging peroxynitrite in the brains of epileptic mice

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