Catalytic enantioselective access to N(iii)-stereogenic aziridines via chiral brønsted acid-catalyzed N–Cl bond formation

Abstract

Herein, we report an enantioselective synthesis of N-stereogenic aziridines through a chiral phosphoric acid-catalyzed asymmetric N-chlorination, enabling the efficient construction of chiral N(III)-stereogenic aziridines under mild conditions.