Active pharmaceutical ingredient–incorporated supramolecular materials as antibacterial agents

Abstract

Active pharmaceutical ingredient (API) metronidazole-incorporated supramolecular materials based on pyridyl-carbamate and their N-oxide derivatives exhibited significant activity against an anaerobic bacterium (P. gingivalis) and were non-toxic to mammalian fibroblast cells. The findings demonstrate a promising approach for developing API-incorporated supramolecular materials as antibacterial agents.