From the journal:

Chemical Communications

Metal-free intramolecular trifluoromethylthiolation/selenolation of alkynes

Chun-Hua Yang, ORCID logo a   Yinchao Zhang,b   Jinze He,a   Yue Xia,a   Xiangtao Kong ORCID logo *a  and  Zhantao Yang ORCID logo *a  

* Corresponding authors

a Henan Key Laboratory of New Opto-electronic Functional Materials, Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University, 436 Xian’ge Road, Anyang, Henan, P. R. China
E-mail: zhantaoyang@163.com

b NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China

Abstract

A metal-free electrophilic trifluoromethylthiolation/selenolation has been developed. Electrophilic SCF3/SeCF3 species generated from trifluoromethyl sulfoxide/selenoxide and Tf2O are successfully coupled with alkynes bearing pendant nucleophiles to obtain the corresponding trifluoromethylthiolation/selenolation and cyclization products in good to high yields.

Graphical abstract: Metal-free intramolecular trifluoromethylthiolation/selenolation of alkynes

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Article information

DOI
https://doi.org/10.1039/D6CC02138G
Article type
Communication
Submitted
08 Apr 2026
Accepted
31 May 2026
First published
02 Jun 2026

Chem. Commun., 2026, Advance Article

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Metal-free intramolecular trifluoromethylthiolation/selenolation of alkynes

C. Yang, Y. Zhang, J. He, Y. Xia, X. Kong and Z. Yang, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC02138G

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