PCN-224-Pt nanozyme for dual-mode detection of acetylcholinesterase via LMB-PEG

Weiyi Bai; Ling Teng; Xingzhi Yu; Qing Li; Huiling Tan; Yongchao Yao; Shufen Li; Limei Zhang; Hao Bai; Imran Shakir; Weihua Zhuang; Yuan Yang; Xuping Sun; Walter (Wenchuang) Hu

doi:10.1039/D6CC02043G

PCN-224-Pt nanozyme for dual-mode detection of acetylcholinesterase viaLMB-PEG

Weiyi Bai,

†^a Ling Teng,†^a Xingzhi Yu,^a Qing Li,^a Huiling Tan,^a Yongchao Yao,

^a Shufen Li,^b Limei Zhang,^a Hao Bai,^a Imran Shakir,^c Weihua Zhuang,

*^a Yuan Yang,*^d Xuping Sun*^ef and Walter (Wenchuang) Hu

*^a

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* Corresponding authors

^a Department of Laboratory Medicine, Precision Medicine Translational Research Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
E-mail: weihuaz@scu.edu.cn, huwenchuang@wchscu.cn

^b Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

^c Department of Physics, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia

^d Department of Pathogen Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China
E-mail: yang_yuan@scu.edu.cn

^e Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
E-mail: xpsun@uestc.edu.cn

^f College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, Shandong, China

Abstract

Alzheimer's disease (AD) is closely associated with cholinergic dysfunction, with acetylcholinesterase (AChE) as a key biomarker. Here, a dual-mode colorimetric/fluorescent platform based on PCN-224-Pt nanozyme and LMB-PEG is developed, enabling rapid, sensitive AChE detection with broad linear ranges, low limits, and improved selectivity, stability, and anti-interference for neurodegenerative disease diagnosis.

Chemical Communications

PCN-224-Pt nanozyme for dual-mode detection of acetylcholinesterase viaLMB-PEG

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PCN-224-Pt nanozyme for dual-mode detection of acetylcholinesterase via LMB-PEG

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