From the journal:

Chemical Communications

Multiplexed digital colloid-enhanced Raman spectroscopy for metabolite detection via selective molecular affinity

Shuang Ni,a   Zhewen Luo,a   Xinyuan Bi,a   Haoran Chen,a   Zehou Su,a   Linley Li Lin ORCID logo *a  and  Jian Ye ORCID logo *abcd  

* Corresponding authors

a State Key Laboratory of Systems Medicine for Cancer, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China
E-mail: yejian78@sjtu.edu.cn, linli92@sjtu.edu.cn

b Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, P.R. China

c Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

d Shanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, P.R. China

Abstract

We construct a dual-nanoparticle platform with complementary affinities for broad metabolite capture and integrate it with digital colloid-enhanced Raman spectroscopy to enable sensitive multiplex quantification in low-concentration mixtures.

Graphical abstract: Multiplexed digital colloid-enhanced Raman spectroscopy for metabolite detection via selective molecular affinity

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Article information

DOI
https://doi.org/10.1039/D6CC01952H
Article type
Communication
Submitted
31 Mar 2026
Accepted
21 May 2026
First published
26 May 2026

Chem. Commun., 2026, Advance Article

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Multiplexed digital colloid-enhanced Raman spectroscopy for metabolite detection via selective molecular affinity

S. Ni, Z. Luo, X. Bi, H. Chen, Z. Su, L. L. Lin and J. Ye, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC01952H

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