Chiral resolution of racemic ibuprofen sodium via diastereomeric ionic cocrystallization with proline

Abstract

Diasteriomeric ionic cocrystallization is introduced as a novel crystallization-based resolution tool. RS-Ibuprofen sodium is succesfully resolved using proline as a resolution agent, achieving ee > 90% in a single resolution step. This work, for the first time, demonstrates diastereomeric ionic cocrystallization as a powerful approach to chiral resolution.