Type I photosensitizer-responsive self-immolative polymers: combining drug release with photodynamic therapy

Chula Sa; Lixia Liu; Lu Qiao; Heng Wu; Yuqing Qiao; Hui-Qing Peng; Wei Cao

doi:10.1039/D6CC01156J

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Type I photosensitizer-responsive self-immolative polymers: combining drug release with photodynamic therapy

Chula Sa,^a Lixia Liu,^a Lu Qiao,^b Heng Wu,^b Yuqing Qiao,^a Hui-Qing Peng

*^b and Wei Cao

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
E-mail: caowei@bnu.edu.cn

^b Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
E-mail: hqpeng@mail.buct.edu.cn

Abstract

In this work, we present self-immolative polymeric micelles (SIPMs) capable of undergoing cascade degradation triggered by superoxide anions (O₂⁻˙) generated from type I photosensitizers (PSs). This process enables controlled drug release and type I photodynamic therapy (PDT) to amplify tumor-cell cytotoxicity, providing a platform that combines self-immolative polymer delivery systems with type I PDT.

This article is part of the themed collection: 2026 Emerging Investigator Collection

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DOI: https://doi.org/10.1039/D6CC01156J
Article type: Communication
Submitted: 24 Feb 2026
Accepted: 19 Mar 2026
First published: 23 Mar 2026

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Chem. Commun., 2026, Advance Article

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Type I photosensitizer-responsive self-immolative polymers: combining drug release with photodynamic therapy

C. Sa, L. Liu, L. Qiao, H. Wu, Y. Qiao, H. Peng and W. Cao, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC01156J

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Type I photosensitizer-responsive self-immolative polymers: combining drug release with photodynamic therapy

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Type I photosensitizer-responsive self-immolative polymers: combining drug release with photodynamic therapy

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