From the journal:

Chemical Communications

Enantioselective construction of chiral quinoline scaffold via a Michael addition/O-alkylation sequence

Juelian Wang,a   Yue Wei,a   Yihuan Yang,a   Guishun Bai,a   Yi Hua,a   Jianwei Chen,a   Hong Wang, ORCID logo *acd   Damien Bonne ORCID logo *b  and  Xiaoze Bao ORCID logo *ad  

* Corresponding authors

a College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
E-mail: hongw@zjut.edu.cn, baoxiaoze@zjut.edu.cn

b Aix Marseille Univ, CNRS, Centrale Med, iSm2, Marseille, France
E-mail: damien.bonne@univ-amu.fr

c Jianxing Honors College, Zhejiang University of Technology, No. 288 Liuhe Road Xihu Area, Hangzhou 310023, China

d Zhejiang-Egypt Joint Laboratory on Intelligent Discovery of Marine Drugs, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

An enantioselective Michael/O-alkylation cascade between hydroxyquinolines and chloronitroalkenes was developed, constructing chiral dihydrofuroquinoline scaffolds in high enantioselectivity under mild conditions. The direct modification of hydroxylcamptothecin and the discovery of anti-tumour (MCF-7 cell lines) leads highlight the potential of this process.

Graphical abstract: Enantioselective construction of chiral quinoline scaffold via a Michael addition/O-alkylation sequence

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Article information

DOI
https://doi.org/10.1039/D6CC00882H
Article type
Communication
Submitted
10 Feb 2026
Accepted
23 Mar 2026
First published
24 Mar 2026

Chem. Commun., 2026, Advance Article

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Enantioselective construction of chiral quinoline scaffold via a Michael addition/O-alkylation sequence

J. Wang, Y. Wei, Y. Yang, G. Bai, Y. Hua, J. Chen, H. Wang, D. Bonne and X. Bao, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00882H

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