Nickel-catalyzed intramolecular defluorinative [4+2] cycloaddition for the construction of monofluoroarenes with gem-difluoroalkenes

Abstract

A nickel-catalyzed defluorinative [4+2] cycloaddition has been developed for the direct synthesis of monofluoroarenes. This method employs gem-difluoroalkenes as effective surrogates for scarce 1-fluoroalkyne precursors, thereby circumventing conventional late-stage aromatic fluorination.