From the journal:

Chemical Communications

Copper-catalyzed spirocyclization–oxytrifluoromethylation of alkynyl-bicyclo[1.1.0]butanes for spirobutyl quinolone synthesis

Peng-Cheng Xu,a   Yin Xu,b   Yu-Ting Wang,c   Jia-Ling Mao,a   Xu Teng,a   Yu-Yang Zhao,a   Xiao Zou,a   Sheng-Hu Yan,*a   Zheng-Ren Jia*b  and  Hang-Dong Zuo ORCID logo *c  

* Corresponding authors

a School of Pharmacy, Changzhou University, Changzhou, Jiangsu 213164, P. R. China
E-mail: ysh@cczu.edu.cn

b Huaian Chenhua New Material Co., Ltd., Huaian, Jiangsu 223001, P. R. China
E-mail: jzr_2001@126.com

c School of Safety Science and Engineering, Changzhou University, Changzhou, Jiangsu 213164, China
E-mail: zhd0513@cczu.edu.cn

Abstract

A Cu-catalyzed radical-initiated spirocyclization-oxytrifluoromethylation gave spirobutyl quinolones under mild conditions with high atom economy. The products showed versatile late-stage reactivity; one acted as a dual optical sensor for Cr6+ and Ba2+, highlighting practical utility.

Graphical abstract: Copper-catalyzed spirocyclization–oxytrifluoromethylation of alkynyl-bicyclo[1.1.0]butanes for spirobutyl quinolone synthesis

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Article information

DOI
https://doi.org/10.1039/D6CC00749J
Article type
Communication
Submitted
04 Feb 2026
Accepted
11 Mar 2026
First published
13 Mar 2026

Chem. Commun., 2026, Advance Article

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Copper-catalyzed spirocyclization–oxytrifluoromethylation of alkynyl-bicyclo[1.1.0]butanes for spirobutyl quinolone synthesis

P. Xu, Y. Xu, Y. Wang, J. Mao, X. Teng, Y. Zhao, X. Zou, S. Yan, Z. Jia and H. Zuo, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00749J

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