In situ forming thermally shrinkable electrospun nanofiber membranes for wound healing

Tianci Sun; Xu Yan; Bin Xia; Xiaofei Shen; Weiwei Fang; Wanchuan Xu; Zihui Fan; Yunfeng Yao; Longxiang Tang; Yunjun Xu; Lei Xia; Qing Li; Xiaopeng Ma; Rende Ning; Tao He

doi:10.1039/D6CC00597G

In situ forming thermally shrinkable electrospun nanofiber membranes for wound healing

Tianci Sun,†^a Xu Yan,†^a Bin Xia,†^a Xiaofei Shen,†^a Weiwei Fang,^a Wanchuan Xu,^a Zihui Fan,^a Yunfeng Yao,^a Longxiang Tang,^a Yunjun Xu,^b Lei Xia,^a Qing Li,*^c Xiaopeng Ma,*^d Rende Ning*^e and Tao He

*^a

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^a School of Chemistry and Chemical Engineering, Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Anhui Province Engineering Research Center of Flexible and Intelligent Materials, Hefei University of Technology, Hefei, Anhui 230009, P. R. China
E-mail: taohe@hfut.edu.cn

^b Department of Radiology, The First Affiliated Hospital of USTC University of Science and Technology of China, Hefei, Anhui 230036, P. R. China

^c Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P.R. China

^d Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, No. 17, Lu Jiang Road, Hefei, Anhui Province 230001, P. R. China

^e The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Anhui, P. R. China

Abstract

Herein, we report a thermo-responsive self-shrinking electrospun dressing. Upon skin contact, it achieves 70% active contraction, leading to 60% wound closure in mice within 24 hours and nearly complete healing of MRSA-infected wounds in 2 weeks. This suture-free dressing simplifies care and avoids suture-related complications.

Chemical Communications

In situ forming thermally shrinkable electrospun nanofiber membranes for wound healing

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In situ forming thermally shrinkable electrospun nanofiber membranes for wound healing

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