Photoredox-catalysed arylamination of non-anomeric exoglycals with aryl sulfinamides via radical Smiles rearrangement

Abstract

Non-anomeric exocyclic glycals have received less research attention, while 1,2-glycals are widely studied as synthetic precursors for oligosaccharides and glycosylation. This study addresses this gap by utilizing photoredox conditions with aryl sulfinamides as bifunctional reagents to modify non-anomeric exocyclic glycals, thereby synthesizing a series of 5-aryl-6-amino glycosyl derivatives under mild conditions.